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Mob.:
+86 156 3115 5652
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thinkdo_calvin@126.com/thinkdochem@126.comAs a chelating agent, GLDA molecules contain multiple active groups that can bind to metal ions. The oxygen atoms on the carboxyl and acetic acid groups of glutamic acid can provide lone pair electrons, forming coordination bonds with metal ions. This chelating effect has strong selectivity and has different chelating abilities for different metal ions, but generally has good chelating effects on common metal ions such as calcium, magnesium, iron, and copper.
| Item | Liquid Grade (38% Active Content) | Solid Grade (98% Purity) |
| CAS No. | 51981-21-6 | 51981-21-6 |
| Appearance | Colorless to light yellow transparent liquid | White crystalline powder, odorless |
| Active Content | ≥38.0% | ≥98.0% |
| pH Value (1% Solution) | 10.5~12.5 | 11.0~13.0 |
| Solubility in Water (25℃) | Completely soluble, ≥180 g/L | Completely soluble, ≥200 g/L |
| Biodegradation Rate (28 days) | ≥95% | ≥95% |
| Melting Point (Solid Grade) | — | 220~225℃ (decomposition) |
| Density (Liquid Grade, 25℃) | 1.25~1.30 g/cm³ | — |
| Heavy Metal Content | ≤5 ppm | ≤5 ppm |
Note: All specifications for Tetrasodium Glutamate Diacetate (GLDA-4Na) comply with relevant national and international standards. Customized grades and concentrations can be provided based on specific application requirements.
Tetrasodium Glutamate Diacetate, commonly referred to as GLDA-4Na, is a water-soluble chelating agent derived from natural L-glutamic acid, with a molecular formula of C9H13NO8·4Na. It is produced through a mild chemical synthesis process that ensures high purity, consistent performance, and low environmental impact. As a green and sustainable chelating agent, it is widely used across multiple industries due to its ability to form stable complexes with various metal ions.
GLDA-4Na works by chelating metal ions such as calcium, magnesium, iron, copper, and zinc, preventing them from participating in unwanted chemical reactions. This mechanism makes it effective for scale inhibition, nutrient enhancement, and formulation stabilization, while its biodegradable nature aligns with global environmental regulations and sustainability trends. It is compatible with most common additives and maintains stability in a wide range of conditions, making it a practical choice for diverse applications.
• Fully Biodegradable: Breaks down completely within 28 days in natural environments, meeting international biodegradation standards and avoiding long-term environmental accumulation.
• High Solubility & Chelating Power: Fully soluble in water at room temperature, and forms stable complexes with a broad range of metal ions, even in low concentrations.
• Low Toxicity & High Safety: Non-irritating to human skin and eyes, non-toxic to aquatic organisms at recommended doses, and safe for use in food-contact and cosmetic applications.
• Excellent Compatibility: Mixes well with surfactants, fertilizers, pesticides, cosmetics ingredients, and industrial additives without precipitation or reduced efficacy.
• Broad pH Adaptability: Maintains stable chelating performance across a pH range of 2.0–12.0, suitable for acidic, neutral, and alkaline application scenarios.
GLDA-4Na is widely used in industrial water treatment as a scale inhibitor, corrosion inhibitor, and metal ion sequestering agent, suitable for circulating water systems, boilers, cooling towers, and industrial cleaning processes.
• Scale Inhibition: Prevents the formation of calcium carbonate, calcium sulfate, and magnesium scale on equipment surfaces, improving heat transfer efficiency and reducing energy consumption.
• Metal Sequestration: Chelates heavy metal ions (such as iron, copper, and nickel) in water, preventing metal corrosion and extending the service life of industrial equipment and pipelines.
• Industrial Cleaning Auxiliary: Used in industrial cleaning formulations to remove scale and metal deposits from equipment surfaces, improving cleaning efficiency without damaging the equipment.
In agriculture, GLDA-4Na serves as a trace element chelating agent and fertilizer synergist, suitable for all types of crops (such as grains, fruits, vegetables) and various soil conditions.
• Trace Element Chelation: Binds iron, zinc, manganese, copper, and other trace elements, preventing them from being fixed in the soil and making them easily absorbable by crops. This helps prevent nutrient deficiency diseases (such as leaf chlorosis and stunted growth).
• Fertilizer Synergist: When mixed with nitrogen, phosphorus, and potassium fertilizers, it improves the absorption rate of nutrients by crops, reduces nutrient leaching, and enhances fertilizer utilization efficiency, thereby reducing environmental pollution caused by excessive fertilizer use.
• Soil Remediation: Helps release trace elements locked in the soil, improves soil fertility, and reduces the need for additional trace element fertilizers.
GLDA-4Na is an important ingredient in household and institutional cleaning products, thanks to its chelating and cleaning-enhancing properties.
• Laundry Detergents: Prevents mineral deposits on fabrics and washing machines, improves cleaning performance, and keeps fabrics bright and soft.
• Dishwashing Liquids & Tablets: Breaks down hard water minerals, prevents water spots on dishes and glassware, and improves foam stability and cleaning efficiency.
• All-Purpose Cleaners: Removes mineral deposits and hard water stains from surfaces such as sinks, tiles, and glass, enhancing cleaning effectiveness.
GLDA-4Na is used in personal care and cosmetic products as a chelating agent to improve product stability and performance.
• Skin Care Products: Chelates metal ions in the formula, preventing oxidation and discoloration of ingredients, and extending the shelf life of products.
• Hair Care Products: Reduces mineral buildup on hair caused by hard water, improving hair manageability and preventing dullness and dryness.
• Cosmetics: Maintains product stability by preventing metal ion-induced chemical reactions, ensuring consistent color, texture, and efficacy of cosmetics.
• Food Industry: Used as a food additive (chelating agent) to prevent oxidation of food ingredients, maintain food quality and freshness, and meet international food safety standards.
• Textile Industry: Used in textile printing and dyeing processes to chelate metal ions in water, improving dyeing uniformity and color fastness, and preventing fabric discoloration.
• Pharmaceutical Industry: Used as a chelating agent in pharmaceutical formulations to improve drug stability and bioavailability, and reduce the impact of metal ions on drug efficacy.
• Soil Remediation: Used in the remediation of heavy metal-contaminated soil to chelate heavy metal ions, reducing their bioavailability and preventing them from spreading to groundwater.
As a fully biodegradable chelating agent, GLDA-4Na decomposes into non-toxic byproducts (glutamic acid, acetic acid, and sodium ions) in natural environments, avoiding soil and water pollution. It is a viable alternative to non-biodegradable chelators such as EDTA and NTA, which tend to accumulate in ecosystems.
Its unique molecular structure allows it to bind tightly to metal ions, even in low concentrations and extreme conditions (high temperature, wide pH range). This ensures reliable performance in scenarios such as industrial water treatment, where scale formation and metal corrosion need to be controlled.
GLDA-4Na is non-irritating to human skin and eyes, and poses no significant risk to aquatic organisms when used as directed. Its safety credentials make it suitable for food-contact applications, cosmetics, and organic agriculture, where product safety is a critical requirement.
It is widely used in industrial water treatment, agriculture, household cleaning, personal care, and other fields. Its compatibility with other chemicals allows it to be easily integrated into existing formulations without requiring major adjustments, reducing formulation costs and complexity.
Although its unit cost may be slightly higher than traditional chelators, GLDA-4Na’s high chelating efficiency means less product is needed to achieve the desired effect. This reduces overall usage volume and long-term operational costs, especially in large-scale industrial applications.
Unlike some chelating agents that lose effectiveness in acidic or alkaline environments, GLDA-4Na maintains stable chelating performance across a wide pH range (2.0–12.0) and can withstand high temperatures (up to 120℃), making it suitable for harsh application scenarios.

1. Difficulty in complying with environmental regulations due to the use of non-biodegradable chelators, leading to regulatory penalties or restricted market access.
Solution: GLDA-4Na is fully biodegradable and meets global environmental standards (such as OECD biodegradation tests). It can directly replace non-biodegradable chelators like EDTA, helping businesses avoid regulatory fines and meet the growing market demand for sustainable products.
2. Scale formation in industrial equipment (such as boilers, circulating water systems) reduces operational efficiency and increases maintenance costs.
Solution: GLDA-4Na effectively chelates calcium, magnesium, and other metal ions in water, preventing the formation of scale on equipment surfaces. This reduces maintenance frequency, extends equipment service life, and ensures the stable operation of industrial systems.
3. Low availability of trace elements in agricultural soils, leading to crop nutrient deficiencies, stunted growth, and reduced yields.
Solution: GLDA-4Na chelates iron, zinc, manganese, and other trace elements, preventing them from being fixed by soil components (such as clay and carbonate). This makes nutrients more accessible to crop roots, improving nutrient absorption efficiency, reducing fertilizer waste, and boosting crop yields.
4. Irritation or toxicity of chelating agents poses risks to workers, consumers, or the environment.
Solution: GLDA-4Na’s low toxicity and non-irritating properties make it safe for workers to handle. It is also safe for use in consumer products (such as household cleaners and cosmetics) and does not harm aquatic life when released into waterways, reducing environmental and safety risks.
5. Poor compatibility with other formulation ingredients leads to precipitation, discoloration, or reduced product efficacy.
Solution: GLDA-4Na has excellent compatibility with surfactants, fertilizers, pesticides, cosmetics emulsifiers, and other additives. It does not undergo chemical reactions or form precipitates, ensuring the stability and efficacy of the final product.
6. Chelating agents lose effectiveness in extreme pH or temperature conditions, limiting application scope.
Solution: GLDA-4Na maintains stable chelating performance in both acidic and alkaline environments, as well as in high-temperature processes (such as industrial cleaning and sterilization). This expands its application scope to more challenging scenarios.
• Liquid Grade: Packed in 25kg food-grade plastic barrels or 250kg IBC tanks. Customized packaging (10kg, 100kg barrels) is available for small-batch orders.
• Solid Grade: Packed in 25kg moisture-proof plastic woven bags with an inner polyethylene liner to prevent moisture absorption. Smaller packaging (1kg, 5kg) is available for laboratory, small-scale, or consumer use.
• Labeling: Each package is clearly labeled with the product name (Tetrasodium Glutamate Diacetate, GLDA-4Na), grade, active content, net weight, production date, shelf life, manufacturer, and safety instructions, complying with international labeling standards.
• Storage Conditions: Store in a cool, dry, well-ventilated warehouse, away from direct sunlight and high temperatures (ideal storage temperature: 5–30℃). Do not store outdoors or in humid environments.
• Sealing: Keep packages tightly sealed to prevent moisture absorption (solid grade) or leakage (liquid grade). Store separately from strong acids, oxidants, and other incompatible substances.
• Shelf Life: 12 months for liquid grade and 24 months for solid grade when stored according to recommended conditions. Do not use the product if it shows signs of discoloration, deterioration, or sediment.
• Transportation: Transport as a non-dangerous good. Avoid violent collisions, sun exposure, and rain during transportation. Handle with care to prevent package damage and leakage. For food-grade, pharmaceutical-grade, and cosmetic-grade products, transport in a clean, pollution-free environment.
During use, it is still important to avoid inhaling dust or coming into contact with the skin and eyes. If accidentally touched, rinse immediately with plenty of water.
It should be sealed during storage to prevent moisture and clumping
• Circulating Water Systems: Add liquid GLDA-4Na at a dose of 8–25 mg/L, depending on water hardness and system operating conditions. It can be used alone or mixed with corrosion inhibitors and dispersants for better performance. Continuously feed the product into the system to maintain a stable concentration.
• Boiler Water Treatment: Add liquid GLDA-4Na at a dose of 15–35 mg/L to prevent scale formation. Adjust the dose based on boiler pressure, water hardness, and operating temperature. Regularly test the water quality to ensure the concentration is within the optimal range.
• Industrial Cleaning: Dilute liquid GLDA-4Na to 1–6% (v/v) with water, apply it to the soiled surface, soak for 15–20 minutes, then rinse thoroughly with clean water. For heavy scale, increase the concentration to 6–10% (v/v).
• Foliar Spraying: Dilute liquid GLDA-4Na to 600–1000 times (0.1–0.17% v/v) and spray it on crop leaves during the seedling, flowering, and fruiting stages. Apply once every 7–10 days, for a total of 2–3 applications. Avoid spraying in direct sunlight or high temperatures (above 30℃).
• Root Irrigation: Dilute liquid GLDA-4Na to 1000–1200 times and apply it via drip irrigation or flood irrigation. Use 10–15 kg per mu (1 mu ≈ 0.067 hectares) once or twice per crop growth cycle.
• Fertilizer Mixing: Mix 150–250g of solid GLDA-4Na with 50kg of compound fertilizer or trace element fertilizer, and apply it as base fertilizer or topdressing. Ensure uniform mixing to avoid uneven nutrient distribution.
• Laundry Detergents: Add 0.8–1.2% (w/w) solid GLDA-4Na to detergent formulations, mixing uniformly with surfactants, builders, and other ingredients during production.
• Dishwashing Products: Add 1.5–2.5% (w/w) liquid GLDA-4Na to dishwashing liquids or tablets to improve hard water performance. Adjust the dose based on the desired cleaning effect and water hardness.
• All-Purpose Cleaners: Dilute liquid GLDA-4Na to 0.8–1.2% (v/v) with water, add it to cleaning solutions, and use it according to the product’s usage instructions for surface cleaning.
• Skin Care & Hair Care Products: Add 0.2–0.6% (w/w) solid GLDA-4Na to formulations, mixing uniformly during the production process. Before large-scale production, conduct a small-scale compatibility test with other ingredients (such as emulsifiers and preservatives) to ensure product stability.
Before large-scale use, conduct a small-scale test to determine the optimal dose for specific application scenarios. Avoid contact with strong acids, as this may reduce chelating efficiency. When handling the product, wear gloves and eye protection; if it comes into contact with skin or eyes, rinse thoroughly with clean water immediately. Keep the product away from children and pets, and do not ingest it. For food, pharmaceutical, and cosmetic applications, strictly follow relevant regulatory guidelines and dose limits.
Our sales and technical teams can work with you to understand your requirements and recommend the most appropriate product based on your application and conditions.
Yes, please refer to the safety data sheets provided for each product for detailed handling and safety instructions.
Yes, upon request and subject to certain conditions, we can provide samples for your evaluation and testing.
Yes, we have a dedicated technical support team available to assist customers with any questions or issues related to the use of our products.
We have strict quality control processes in place, including raw material inspection, in-process monitoring, and final product testing to ensure consistent quality.